Illustrated Glossary of Organic Chemistry
Stork
enamine
reaction:
A
Michael addition reaction
in which the
nucleophile
is an
enamine
. Developed by
Gilbert Stork of Columbia University
.
In this Stork
enamine
reaction,
cyclohexanone
is reacted with
pyrrolidine
in the presence of
p
-TsOH
catalysis
to
produce
an
enamine
. This
enamine
undergoes
Michael addition
to
but-3-en
-2-
one
, which (after
hydrolysis
)
produces
2-(3-
oxo
butyl
)
cyclohexan-1-one
, a 1,5-di
ketone
.
Related terms:
Stork acylation reaction
,
name reaction
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